A giant lizard has been spotted in the subways and Jameson is willing to pay $1,000 to the photographer who gets the creature on film. Peter turns to his college professor, Dr. Curt Connors, for answers. But not the answers he expects.
Episode 2: The Sting of the Scorpion
Jameson is becoming obsessed with destroying Spider-Man. So he hires a man named Mac Gargan to try out a new scorpion suit, made in the laboratories of Empire State University. But the mutation of the suit begins to turn Gargan into a monster.
Episode 6: Doctor Octopus - Armed And Dangerous
Doctor Otto Octavius, one of Peter's childhood teachers, gets revenge on the Hardy family for cutting off the funding for his research, by kidnapping Mrs. Hardy's daughter, Felicia.
Episode 7: The Alien Costume: Part 1
John Jameson, Jameson's son, finds a strange black liquid while collecting a rock called Promethium X on the moon. The black liquid finds it's way to Spider-Man, giving him a new black suit and the Kingpin sends Rhino after the Promethium X.
Episode 8: The Alien Costume: Part 2
Spider-Man is becoming attached to his new suit. But Eddie Brock has framed Spider-Man for the Promethium X robbery. Alaster and Kingpin send Shocker after Eddie to dispose of him. Now, Spidey will begin to see what the suit is really worth.
Episode 9: The Alien Costume: Part 3
The symbiote takes over Eddie Brock to give birth to Venom. Now, Spidey must go up against the most dangerous enemy he's ever faced. One who is stronger, more skilled, undetected by his spider-sense, and knows Spidey's true identity.
Episode 10: Kraven the Hunter
Peter has a job interview at the Hardy Foundation Research Center. But his interviewer, Dr. Mariah Crawford, is visited by an old lover, Sergei Kravinoff aka Kraven the Hunter.
Episode 11: The Hobgoblin - Part 1
Norman Osborn hires a psychopath, known as the Hobgoblin, to kill the Kingpin. But the Hobgoblin plans to use Osborn and Kingpin's rivalry to his own advantage.
Episode 2: Battle of the Insidious Six
Spider-Man begins to turn the Insidious Six against each other. But his powers are still giving him problems.
Episode 9: Blade, the Vampire Hunter
With Man-Spider kept at bay, temporarily, Spider-Man now turns to helping Michael Morbius become human once more. But a vampire hunter named Blade is after Morbius as well.
Episode 10: The Immortal Vampire
Spider-Man and Blade team up to stop Morbius from turning Felicia and the rest of the city into vampires.
Episode 13: Shriek of the Vulture
Adrian Toomes finances Dr. Conners new lab for neogenics. But, unknown to everyone, Toomes is actually stealing peoples' youth to have enough strength to take down Norman Osborn, as The Vulture.
Episode 14: The Final Nightmare
The Vulture takes Spider-Man's youth to become young again, but he also absorbs the mutating DNA of Man-Spider. The Scorpion also returns, desperate to become normal again.
Episode 1: Doctor Strange
Now that Spider-Man is free from Man-Spider's curse, his new problem is finding Mary Jane, who has received a mysterious letter from her father.
Episode 2: Make a Wish
Peter is beginning to give up. He's tired of Spider-Man being called a menace when he tries to help. But when he receives a letter from Spidey's #1 fan, Tina, he decides to give Spider-Man one last swing.
Episode 3: Attack of the Octobot
Dr. Octopus has captured Spider-Man and erases his memory. Now, it's up to Taina to save him.
Episode 4: Enter the Green Goblin
After an explosion at Oscorp Industries, Norman Osborn has gone missing. Soon after, a menace called the Green Goblin appears and starts kidnapping the chair members of Oscorp's board.
Episode 5: The Rocket Racer
Robert, a former troublemaker, has been trying to help his mother with her business and her illness. But when a new gang, lead by Big-Wheel, threaten them, Robert takes matters into his own hands.
Episode 6: Framed
When Peter Parker is framed for treason, the only help he has is from Matt Murdock, both as his lawyer and as the superhero Daredevil.